For cells to survive changes in their environment or to be able to thrive in a completely new location, they must sense the change and immediately respond to it. 

The cells must channel their resources wisely, so the most critical cellular functions are fed first. 

For different cells these functions vary, and the mechanisms the cells deploy to quickly adapt are quite diverse. 

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We apply genetic perturbations, biochemical assays, molecular biology, functional genomic screens, and metabolite profiling by mass spectrometry in cell-culture systems and in vivo to study the adaptation mechanisms of immune and cancer cells to new metabolic enviornment.