Selected Publications

  1. Kanarek N, Keys HR, Cantor JR, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Freinkman E, Schweitzer LD and Sabatini DM Histidine catabolism is a major determinant of methotrexate sensitivity. Nature 2018 Jul;559(7715):632-636. doi: 10.1038/s41586-018-0316-7. Epub 2018 Jul 11. view abstract

  2. Cantor JR, Abu-Remaileh M, Kanarek N, Freinkman E, Gao X, Louissaint Jr. A, Lewis CA, Sabatini DM, Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase. Cell 2017 169 (2): 258-272.e17 view abstract

  3. Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM. Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell 2014 Aug 28;158(5):1094-109. doi: 10.1016/j.cell.2014.07.032. view abstract

  4. Horwitz E, Stein I, Andreozzi M, Nemeth J, Shoham A, Pappo O, Schweitzer N, Tornillo L, Kanarek N, Quagliata L, Zreik F, Porat RM, Finkelstein R, Reuter H, Koschny R, Ganten T, Mogler C, Shibolet O, Hess J, Breuhahn K, Grunewald M, Schirmacher P, Vogel A, Terracciano L, Angel P, Ben-Neriah Y, Pikarsky E. Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment. Cancer Discov. 2014 Mar 31. view abstract

  5. Kanarek N, Grivennikov S, Leshets M, Horwitz E, Pagano M, Pikarsky E, Karin M, Ghosh S, and Ben-Neriah Y. A critical role for IL-1ß in DNA damage-induced colitis. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):E702-11. doi: 10.1073/pnas.1322691111. Epub 2014 Jan 27. view abstract

  6. Kanarek N and Ben-Neriah Y. Regulation of NF-kappaB by Ubiquitination and Degradation of the IkBs. Immunol Rev. 2012 Mar;246(1):77-94. view abstract

  7. Duan S, Skaar JF, Toschi A, Kanarek N, Ben-Neriah Y, and Pagano M. mTOR Generates an Auto-Amplification Loop by Triggering the ßTrCP- and CK1a-Dependent Degradation of DEPTOR. Mol Cell. 2011 Oct 21;44(2):317-24. view abstract

  8. Kanarek N, Horwitz E, Mayan I, Leshets M, Cojocaru G, Davis M, Tsuberi BZ, Pikarsky E, Pagano M, and Ben-Neriah Y. Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCF?-TrCP by single substrate depletion. Genes and Dev. Mar 1, 2010; 24 (5). view abstract

  9. Kanarek N, London N, Schueler-Furman O, and Ben-Neriah Y. Ubiquitination and Degradation of the Inhibitors of NF-kB. Cold Spring Harb Perspect Biol. February 2010;2:a000166 view abstract

  10. Zach N, Kanarek N, Inbar D, Grinvald Y, Milestein T, Vaadia E. Segregation between acquisition and long-term memory in sensorimotor learning. Eur J Neurosci. 2005 view abstract

The Kanarek Lab

‚Äč

Department of Pathology

Boston Children Hospital /

Harvard Medical School

Enders 1116.2

300 Longwood Ave

Boston, MA 02115

Lab Phone: (617) 355-7433

Office Phone: (617) 919-7352

Principal Investigator email: 

naama.kanarek@childrens.harvard.edu