Selected Publications

  1. Petrova B, Warren A, Vital NY, Culhane AJ, . Maynard AG, Wong A, Kanarek N. Redox metabolism measurement in mammalian cells and tissues by LC-MS. Metabolites 11(5): 313. view abstract

  2. Diray-Arce J, Conti MG, Petrova B, Kanarek N, Angelidou A, Levy O. Metabolomics to Identify Molecular Signatures of Responses to Vaccines and Infections. Metabolites2020 Nov 30;10(12):E492. doi: 10.3390/metabo10120492. PMID: 33266347 Review. view abstract

  3. Petrova B and Kanarek N. Potential Benefits and Pitfalls of Histidine Supplementation for Cancer Therapy Enhancement. J Nutrition. 2020 Oct 1;150 (Supplement_1) :2580S-2587S. doi: 10.1093/jn/nxaa132. PMID 33000153 view abstract 

  4. Maynard AG and Kanarek N. NADH Ties One-Carbon Metabolism to Cellular Respiration. Cell Metabolism. 2020 Apr 7;31(4):660-662. doi: 10.1016/j.cmet.2020.03.012. view abstract

  5. Kanarek N, Petrova B, and Sabatini DM. Dietary modifications for enhanced cancer therapy. Nature. 2020 Mar;579(7800):507-517. doi: 10.1038/s41586-020-2124-0. Epub 2020 Mar 25. Review PMID: 32214253 view abstract

  6. Kanarek N, Keys HR, Cantor JR, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Freinkman E, Schweitzer LD and Sabatini DM Histidine catabolism is a major determinant of methotrexate sensitivity. Nature 2018 Jul;559(7715):632-636. doi: 10.1038/s41586-018-0316-7. Epub 2018 Jul 11. view abstract

  7. Cantor JR, Abu-Remaileh M, Kanarek N, Freinkman E, Gao X, Louissaint Jr. A, Lewis CA, Sabatini DM, Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase. Cell 2017 169 (2): 258-272.e17 view abstract

  8. Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM. Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell 2014 Aug 28;158(5):1094-109. doi: 10.1016/j.cell.2014.07.032. view abstract

  9. Horwitz E, Stein I, Andreozzi M, Nemeth J, Shoham A, Pappo O, Schweitzer N, Tornillo L, Kanarek N, Quagliata L, Zreik F, Porat RM, Finkelstein R, Reuter H, Koschny R, Ganten T, Mogler C, Shibolet O, Hess J, Breuhahn K, Grunewald M, Schirmacher P, Vogel A, Terracciano L, Angel P, Ben-Neriah Y, Pikarsky E. Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment. Cancer Discov. 2014 Mar 31. view abstract

  10. Kanarek N, Grivennikov S, Leshets M, Horwitz E, Pagano M, Pikarsky E, Karin M, Ghosh S, and Ben-Neriah Y. A critical role for IL-1ß in DNA damage-induced colitis. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):E702-11. doi: 10.1073/pnas.1322691111. Epub 2014 Jan 27. view abstract

  11. Kanarek N and Ben-Neriah Y. Regulation of NF-kappaB by Ubiquitination and Degradation of the IkBs. Immunol Rev. 2012 Mar;246(1):77-94. view abstract

  12. Duan S, Skaar JF, Toschi A, Kanarek N, Ben-Neriah Y, and Pagano M. mTOR Generates an Auto-Amplification Loop by Triggering the ßTrCP- and CK1a-Dependent Degradation of DEPTOR. Mol Cell. 2011 Oct 21;44(2):317-24. view abstract

  13. Kanarek N, Horwitz E, Mayan I, Leshets M, Cojocaru G, Davis M, Tsuberi BZ, Pikarsky E, Pagano M, and Ben-Neriah Y. Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCF?-TrCP by single substrate depletion. Genes and Dev. Mar 1, 2010; 24 (5). view abstract

  14. Kanarek N, London N, Schueler-Furman O, and Ben-Neriah Y. Ubiquitination and Degradation of the Inhibitors of NF-kB. Cold Spring Harb Perspect Biol. February 2010;2:a000166 view abstract

  15. Zach N, Kanarek N, Inbar D, Grinvald Y, Milestein T, Vaadia E. Segregation between acquisition and long-term memory in sensorimotor learning. Eur J Neurosci. 2005 view abstract