October 2019 - our fancy mass-specs are here!
Selected Publications
Tong X, Remsik J, Brook JR, Petrova B, Xu L, Li MJ, Snyder J, Chabot K, Estrera R, Osei-Gyening I, Nobre AR, Wang H, Osman AM, Wong AYL, Sidharta M, Piedrafita-Ortiz S, Manoranjan B, Zhou T, Murali R, Hamard P-J, Koche R, He Y, Kanarek N, Boire A*
Retinoid X Receptor Signaling Mediates Cancer Cell Lipid Metabolism in the Leptomeninges
bioRxiv 2024 Oct 15:2024.10.13.618083. doi: 10.1101/2024.10.13.618083. view abstract
Ferro LS, Wong AYL, Howland J, Costa ASH, Pruyne JG, Shah D, Lauterbach JD, Hooper SB, Cadosch Delmar M, Geremia J, Kassis T, Kanarek N*, Campbell JM*
A scalable approach to absolute quantitation in metabolomics
bioRxiv. 2024.09.09.609906; doi: https://doi.org/10.1101/2024.09.09.609906 view abstract
Chen WW, Pacold ME, Sabatini DM and Kanarek N*
Technologies for Decoding Cancer Metabolism with Spatial Resolution
Cold Spring Harbor Perspective. September 2024 Sep 16:a041553. doi: 10.1101/cshperspect.a041553. view abstract
Petrova B*, Lacey TE, Culhane AJ, Cui J, Brook JR, Raskin A, Misra A, Lehtinen MK, and Kanarek N*.
Profiling metabolome of mouse embryonic cerebrospinal fluid following maternal immune activation
J Biol Chem. 2024 Sep 7:107749. doi: 10.1016/j.jbc.2024.107749. view abstract
Mertens RT, Misra A, Xiao P, Baek S, Rone JM, Mangani D, Sivanathan KN, Arojojoye AS, Awuah SG, Lee I, Shi G-P, Petrova B, Brook JR, Anderson AC, Flavell RA, Kanarek N, Hemberg M, Nowarski R*
A metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance
Immunity 2024, Jun 19:S1074-7613(24)00305-4. doi: 10.1016/j.immuni.2024.06.001 view abstract
Fame RM*, Ali I, Lehtinen MK, Kanarek N and Petrova B*.
Optimized Mass Spectrometry Detection of Thyroid Hormones 2 and Polar Metabolites in Rodent Cerebrospinal Fluid
Metabolites 2024, 14, 79. https://doi.org/10.3390/metabo14020079 view abstract
Maynard AG, Pohl NK, Petrova B, Wong AYL, Wang P, Culhane AJ, Hirsch L, Hoang N, Kirkland O, Braun T, Ducamp S, Fleming MD, Li H, and Kanarek N*.
Folate depletion induces erythroid differentiation through perturbation of de novo purine synthesis.
Science Advances 10,eadj9479 (2024). DOI:10.1126/sciadv.adj9479 view abstract
Petrova B, Maynard AG, Wang P, and Kanarek N*.
Regulatory mechanisms of one-carbon metabolism enzymes.
J Biol Chem. 2023 Nov 8:105457. doi: 10.1016/j.jbc.2023.105457. view abstract
Dreishpoon MB, Bick NR, Petrova B, Warui DM, Cameron A, Booker SJ, Kanarek N, Golub TR, Tsvetkov P.
FDX1 regulates cellular protein lipoylation through direct binding to LIAS.
J Biol Chem. 2023 Jul 13;105046. doi: 10.1016/j.jbc.2023.105046. view abstract
Kramer NJ, Prakash G, Isaac RS, Choquet K, Soto I, Petrova B, Merens HE, Kanarek N, Churchman LS.
Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression
Nature Cell Biology. 2023 Nov;25(11):1575-1589. doi: 10.1038/s41556-023-01244-3. Epub 2023 Sep 28 view abstract
Hogstrom J, Cruz KA, Selfors LM, Ward MN, Warren A, Weden V, Mehta TS, Kanarek N, Collins LC, Patel JM, Muranen T.
Simultaneous isolation of hormone receptor positive breast cancer organoids and fibroblasts reveals stroma-mediated resistance mechanisms.
J Biol Chem. 2023 Jul 7;105021. doi: 10.1016/j.jbc.2023.105021. view abstract
Fame RM, Kalugin PN, Petrova B, Xu H, Soden PA, Shipley FB, Dani N, Grant B, Pragana A, Head JP, Gupta S, Shannon ML, Chifamba FF, Hawks-Mayer H, Vernon A, Gao F, Zhang Y, Holtzman MJ, Heiman M, Andermann ML, Kanarek N, Lipton JO, Lehtinen MK.
Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution.
Nat Commun. 2023 Jun 22;14(1):3720. doi: 10.1038/s41467-023-39326-3. PubMed PMID: 37349305. view abstract
Brown JI, Wang P, Wong AYL, Petrova B, Persaud R, Soukhtehzari S, McDonald ML, Hanke D, Christensen J, Iliev P, Wang W, Everton DK, Williams KC, Frank DA, Kanarek N, Page BDG.
Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity.
Metabolites. 2023 Jan 19;13(2):151. doi: 10.3390/metabo13020151. view abstract
Jang A, Petrova B, Cheong T-C, Zawadzki ME, Jones JK, Culhane AJ, Shipley FB, Chiarle R, Wong ET, Kanarek N*, Lehtinen MK*.
Choroid plexus - CSF targeted antioxidant therapy protects the brain from toxicity of cancer chemotherapy.
Neuron 2022. Sep 1;S0896-6273(22)00741-3. doi: 10.1016/j.neuron.2022.08.009. view abstract
Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R, Spangler RD, Eaton JK, Frenkel E, Kocak M, Corsello SM, Lutsenko S, Kanarek N, Santagata S, Golub TR.
Copper induces cell death by targeting lipoylated TCA cycle proteins.
Science 2022 Mar 18;375(6586):1254-1261. view abstract
Heppler LN, Attarha S, Persaud R, Brown JI, Wang P, Petrova B, Tošić I, Burton FB, Flamand Y, Walker SR, Yeh JE, Zubarev RA, Gaetani M, Kanarek N, Page BDG, Frank DA.
The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase.
J Biol Chem. 2021 Dec 22:101531. view abstract
Petrova B, Warren A, Vital NY, Culhane AJ, . Maynard AG, Wong A, Kanarek N*.
Redox metabolism measurement in mammalian cells and tissues by LC-MS.
Metabolites 2021 May 13;11(5):313. doi: 10.3390/metabo11050313.. view abstract
Diray-Arce J, Conti MG, Petrova B, Kanarek N, Angelidou A, Levy O.
Metabolomics to Identify Molecular Signatures of Responses to Vaccines and Infections.
Metabolites. 2020 Nov 30;10(12):E492. doi: 10.3390/metabo10120492. PMID: 33266347 Review. view abstract
Petrova B and Kanarek N*.
Potential Benefits and Pitfalls of Histidine Supplementation for Cancer Therapy Enhancement.
J Nutrition. 2020 Oct 1;150 (Supplement_1) :2580S-2587S. doi: 10.1093/jn/nxaa132. PMID 33000153 view abstract
Maynard AG and Kanarek N*.
NADH Ties One-Carbon Metabolism to Cellular Respiration.
Cell Metabolism. 2020 Apr 7;31(4):660-662. doi: 10.1016/j.cmet.2020.03.012. view abstract
Kanarek N*, Petrova B, and Sabatini DM.
Dietary modifications for enhanced cancer therapy.
Nature. 2020 Mar;579(7800):507-517. doi: 10.1038/s41586-020-2124-0. Epub 2020 Mar 25. Review PMID: 32214253 view abstract
Kanarek N, Keys HR, Cantor JR, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Freinkman E, Schweitzer LD and Sabatini DM
Histidine catabolism is a major determinant of methotrexate sensitivity.
Nature 2018 Jul;559(7715):632-636. doi: 10.1038/s41586-018-0316-7. Epub 2018 Jul 11. view abstract
Cantor JR, Abu-Remaileh M, Kanarek N, Freinkman E, Gao X, Louissaint Jr. A, Lewis CA, Sabatini DM,
Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase.
Cell 2017 169 (2): 258-272.e17 view abstract
Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM.
Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.
Cell 2014 Aug 28;158(5):1094-109. doi: 10.1016/j.cell.2014.07.032. view abstract
Horwitz E, Stein I, Andreozzi M, Nemeth J, Shoham A, Pappo O, Schweitzer N, Tornillo L, Kanarek N, Quagliata L, Zreik F, Porat RM, Finkelstein R, Reuter H, Koschny R, Ganten T, Mogler C, Shibolet O, Hess J, Breuhahn K, Grunewald M, Schirmacher P, Vogel A, Terracciano L, Angel P, Ben-Neriah Y, Pikarsky E.
Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment.
Cancer Discov. 2014 Mar 31. view abstract
Kanarek N, Grivennikov S, Leshets M, Horwitz E, Pagano M, Pikarsky E, Karin M, Ghosh S, and Ben-Neriah Y. A Critical role for IL-1ß in DNA damage-induced colitis.
Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):E702-11. doi: 10.1073/pnas.1322691111. Epub 2014 Jan 27. view abstract
Kanarek N and Ben-Neriah Y.
Regulation of NF-kappaB by Ubiquitination and Degradation of the IkBs.
Immunol Rev. 2012 Mar;246(1):77-94. view abstract
Duan S, Skaar JF, Toschi A, Kanarek N, Ben-Neriah Y, and Pagano M.
mTOR Generates an Auto-Amplification Loop by Triggering the ßTrCP- and CK1a-Dependent Degradation of DEPTOR.
Mol Cell. 2011 Oct 21;44(2):317-24. view abstract
Kanarek N, Horwitz E, Mayan I, Leshets M, Cojocaru G, Davis M, Tsuberi BZ, Pikarsky E, Pagano M, and Ben-Neriah Y.
Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCF beta-TrCP by single substrate depletion.
Genes and Dev. Mar 1, 2010; 24 (5). view abstract
Kanarek N, London N, Schueler-Furman O, and Ben-Neriah Y.
Ubiquitination and Degradation of the Inhibitors of NF-kB.
Cold Spring Harb Perspect Biol. February 2010;2:a000166 view abstract
Zach N, Kanarek N, Inbar D, Grinvald Y, Milestein T, Vaadia E.
Segregation between acquisition and long-term memory in sensorimotor learning.
Eur J Neurosci. 2005 view abstract