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Selected Publications


Maynard AG, Pohl NK, Petrova B, Wong AYL, Wang P, Culhane AJ, Hirsch L, Hoang N, Kirkland O, Braun T, Ducamp S, Fleming MD, Li H, and Kanarek N*.

Folate depletion induces erythroid differentiation through perturbation of de novo purine synthesis.

bioRxiv 2022.12.22.521608;


Petrova B, Maynard AG, Wang P, and Kanarek N*.

Regulatory mechanisms of one-carbon metabolism enzymes.

J Biol Chem. In Press.


Dreishpoon MB, Bick NR, Petrova B, Warui DM, Cameron A, Booker SJ, Kanarek N, Golub TR, Tsvetkov P.

FDX1 regulates cellular protein lipoylation through direct binding to LIAS.

J Biol Chem. 2023 Jul 13;105046. doi: 10.1016/j.jbc.2023.105046. view abstract


Kramer NJ, Prakash G, Choquet K, Soto I, Petrova B, Merens HE, Kanarek N, Churchman LS.

Genome-wide screens for mitonuclear co-regulators uncover links between compartmentalized metabolism and mitochondrial gene expression.

Nature Cell Biology. In Press 

Hogstrom J, Cruz KA, Selfors LM, Ward MN, Warren A, Weden V, Mehta TS, Kanarek N, Collins LC, Patel JM, Muranen T.

Simultaneous isolation of hormone receptor positive breast cancer organoids and fibroblasts reveals stroma-mediated resistance mechanisms.   

J Biol Chem. 2023 Jul 7;105021. doi: 10.1016/j.jbc.2023.105021. view abstract

Fame RM, Kalugin PN, Petrova B, Xu H, Soden PA, Shipley FB, Dani N, Grant B, Pragana A, Head JP, Gupta S, Shannon ML, Chifamba FF, Hawks-Mayer H, Vernon A, Gao F, Zhang Y, Holtzman MJ, Heiman M, Andermann ML, Kanarek N, Lipton JO, Lehtinen MK.

Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution.

Nat Commun. 2023 Jun 22;14(1):3720. doi: 10.1038/s41467-023-39326-3. PubMed PMID: 37349305. view abstract


Brown JI, Wang P, Wong AYL, Petrova B, Persaud R, Soukhtehzari S, McDonald ML, Hanke D, Christensen J, Iliev P, Wang W, Everton DK, Williams KC, Frank DA, Kanarek N, Page BDG.

Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity. 

Metabolites. 2023 Jan 19;13(2):151. doi: 10.3390/metabo13020151. view abstract

Jang A, Petrova B, Cheong T-C, Zawadzki ME, Jones JK, Culhane AJ, Shipley FB, Chiarle R, Wong ET, Kanarek N*, Lehtinen MK*.

Choroid plexus - CSF targeted antioxidant therapy protects the brain from toxicity of cancer chemotherapy.

Neuron 2022. Sep 1;S0896-6273(22)00741-3.  doi: 10.1016/j.neuron.2022.08.009. view abstract

Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R, Spangler RD, Eaton JK, Frenkel E, Kocak M, Corsello SM, Lutsenko S, Kanarek N, Santagata S, Golub TR.

Copper induces cell death by targeting lipoylated TCA cycle proteins.

Science 2022 Mar 18;375(6586):1254-1261. view abstract


Heppler LN, Attarha S, Persaud R, Brown JI, Wang P, Petrova B, Tošić I, Burton FB, Flamand Y, Walker SR, Yeh JE, Zubarev RA, Gaetani M, Kanarek N, Page BDG, Frank DA.

The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase.

J Biol Chem. 2021 Dec 22:101531. view abstract

Petrova B, Warren A, Vital NY, Culhane AJ, . Maynard AG, Wong A, Kanarek N*.

Redox metabolism measurement in mammalian cells and tissues by LC-MS. 

Metabolites 11(5): 313. view abstract

Diray-Arce J, Conti MG, Petrova B, Kanarek N, Angelidou A, Levy O.

Metabolomics to Identify Molecular Signatures of Responses to Vaccines and Infections.

Metabolites2020 Nov 30;10(12):E492. doi: 10.3390/metabo10120492. PMID: 33266347 Review. view abstract

Petrova B and Kanarek N*.

Potential Benefits and Pitfalls of Histidine Supplementation for Cancer Therapy Enhancement.

J Nutrition. 2020 Oct 1;150 (Supplement_1) :2580S-2587S. doi: 10.1093/jn/nxaa132. PMID 33000153 view abstract 

Maynard AG and Kanarek N*.

NADH Ties One-Carbon Metabolism to Cellular Respiration. 

Cell Metabolism. 2020 Apr 7;31(4):660-662. doi: 10.1016/j.cmet.2020.03.012. view abstract

Kanarek N*, Petrova B, and Sabatini DM.

Dietary modifications for enhanced cancer therapy. 

Nature. 2020 Mar;579(7800):507-517. doi: 10.1038/s41586-020-2124-0. Epub 2020 Mar 25. Review PMID: 32214253 view abstract


Kanarek N, Keys HR, Cantor JR, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Freinkman E, Schweitzer LD and Sabatini DM

Histidine catabolism is a major determinant of methotrexate sensitivity.

Nature 2018 Jul;559(7715):632-636. doi: 10.1038/s41586-018-0316-7. Epub 2018 Jul 11. view abstract


Cantor JR, Abu-Remaileh M, Kanarek N, Freinkman E, Gao X, Louissaint Jr. A, Lewis CA, Sabatini DM,

Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase.

Cell 2017 169 (2): 258-272.e17 view abstract


Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM.

Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.

Cell 2014 Aug 28;158(5):1094-109. doi: 10.1016/j.cell.2014.07.032. view abstract

Horwitz E, Stein I, Andreozzi M, Nemeth J, Shoham A, Pappo O, Schweitzer N, Tornillo L, Kanarek N, Quagliata L, Zreik F, Porat RM, Finkelstein R, Reuter H, Koschny R, Ganten T, Mogler C, Shibolet O, Hess J, Breuhahn K, Grunewald M, Schirmacher P, Vogel A, Terracciano L, Angel P, Ben-Neriah Y, Pikarsky E.

Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment.

Cancer Discov. 2014 Mar 31. view abstract


Kanarek N, Grivennikov S, Leshets M, Horwitz E, Pagano M, Pikarsky E, Karin M, Ghosh S, and Ben-Neriah Y. A Critical role for IL-1ß in DNA damage-induced colitis.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):E702-11. doi: 10.1073/pnas.1322691111. Epub 2014 Jan 27. view abstract


Kanarek N and Ben-Neriah Y.

Regulation of NF-kappaB by Ubiquitination and Degradation of the IkBs.

Immunol Rev. 2012 Mar;246(1):77-94. view abstract

Duan S, Skaar JF, Toschi A, Kanarek N, Ben-Neriah Y, and Pagano M.

mTOR Generates an Auto-Amplification Loop by Triggering the ßTrCP- and CK1a-Dependent Degradation of DEPTOR.

Mol Cell. 2011 Oct 21;44(2):317-24. view abstract

Kanarek N, Horwitz E, Mayan I, Leshets M, Cojocaru G, Davis M, Tsuberi BZ, Pikarsky E, Pagano M, and Ben-Neriah Y.

Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCF beta-TrCP by single substrate depletion.

Genes and Dev. Mar 1, 2010; 24 (5). view abstract

Kanarek N, London N, Schueler-Furman O, and Ben-Neriah Y.

Ubiquitination and Degradation of the Inhibitors of NF-kB.

Cold Spring Harb Perspect Biol. February 2010;2:a000166 view abstract

Zach N, Kanarek N, Inbar D, Grinvald Y, Milestein T, Vaadia E.

Segregation between acquisition and long-term memory in sensorimotor learning.

Eur J Neurosci. 2005 view abstract

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