Immune cells move to sites of inflammation, and must adapt and function fully in very different environments.
Specifically in cancer, immune cells need to adapt to the nutrient-deprived tumor microenvironment in order to clear the tumor.
That's asking a lot!
We think that we can help them to do better once we understand what they really need for successful metabolic adaptation.
Cancer cells manage to adapt to the constantly changing, and increasingly challenging tumor microenvironment.
Moreover - they often migrate to secondary sites, where they face completely new conditions including differences in oxygen, nutrients, and growth factors.
We think that we can outsmart cancer cells by learning about their metabolic vulnerabilities and adaptability capacity.